**How it happens:** Highly caloric food intake causes blood sugar spikes, which causes insulin spikes. If this process goes on for long enough and repeats repeats often enough, the cells start shutting down the doors for insulin, thus forcing the body to produce more of it in order to get rid of the same amount of blood glucose. Insulin resistance is a precursor for [[Diabetes]] and it's directly linked to [[Mitochondria Dysfunction]].